Tucker went down during the team's late practice.
The Lions official web site referred to the injury as a "knee sprain", but the extent of the injury will be learned later this evening after he is given an MRI.
Tucker, who signed on as an unrestricted free-agent in March, has had his career ravaged with lower-leg injuries. In total, the 2001 Pro Bowl alternate he has missed 41 games over the last three seasons.
Despite his injured past, Tucker was penciled in as the team's starting right tackle, the position manned by then-rookie Kelly Butler in 2005. Butler replaced Tucker in the first-team lineup.